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Journal of Child Neurology
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Article

Predictive Factors of Early Mortality in Children With Developmental Disabilities: A Case-Comparison Analysis

Ayala Cohen, PhD1, Eyal Asor, MD2, and Emanuel Tirosh, MD2*

1 Israel Institute of Technology, and The Hannah Khoushy Child Development Center, Haifa, Israel
2 Bnai Zion Medical Center and Faculty of Medicine, Haifa, Israel

* To whom correspondence should be addressed. E-mail: tirosh-e{at}b-zion.org.il.


  Abstract
The aim of this study was to identify the risk factors for early mortality in children with neurodevelopmental disabilities. Of 1000 children who were sequentially referred to the same child developmental center over the period 1975–1985, 81 children died between the ages of 6 months and 22 years (mean, 8.04 years; 6.1 SD). A group of 81 age-matched children and another group of 81 developmentally and age-matched children also referred to the center served as comparison groups. Following multivariate analysis, low developmental quotient, restricted mobility, assisted feeding, and genetic etiology were risk factors for early mortality when compared to the age-matched group (P < .01). In comparison to the developmentally matched group, restricted mobility, genetic etiology, and hearing deficit were identified as significant risk factors (P < .01). Comprehensive treatment at the child development center was demonstrated to be a significant protective factor (P = .004). Socioeconomic variables were not significant in predicting an increased mortality risk in disabled individuals. In conclusion, in addition to mobility and feeding skills, a genetic etiology and hearing deficit are risk factors for early mortality, whereas socioeconomic variables are not. A comprehensive treatment program was found to be a protective factor.

First published on January 9, 2008, doi:10.1177/0883073807309795

Journal of Child Neurology 2008;23:536.

A more recent version of this article appeared on May 1, 2008

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