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Journal of Child Neurology
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0883073808314151v1
23/9/1028    most recent
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Article

Neurologic Manifestations of Pediatric Chikungunya Infection

Stéphanie Robin, MD*, Duksha Ramful, MD, Florence Le Seach', MD, Marie-Christine Jaffar-Bandjee, MD, Gérald Rigou, MD, and Jean-Luc Alessandri, MD

Centre Hospitalier Départemental Félix Guyon, La Réunion, France

* To whom correspondence should be addressed. E-mail: st-robin{at}chd-fguyon.fr.


  Abstract
Chikungunya virus, a mosquito-borne arbovirus, was responsible for a massive epidemic in La Réunion Island during 2005 to 2006. The disease is usually benign, but neurologic involvement, with sometimes fatal outcome, has been described. We report a retrospective hospital-based pediatric series of 30 children (23 boys and 7 girls) who presented neurologic manifestations of chikungunya such as encephalitis (n = 12), febrile seizures (n = 10), meningeal syndrome (n = 4), and acute encephalopathy (n = 4). Cerebrospinal fluid biological and cytological analyses (n = 23) were unremarkable except for 1 case of acute disseminated encephalomyelitis. The presence of viral genome in cerebrospinal fluid was inconstantly positive. Brain magnetic resonance imaging (MRI) scans (n = 14) were abnormal in 5 cases. Electroencephalography was nonspecific. Two patients died. At discharge and 6 months later, 5 children had neurologic sequelae. Patients with initial severe neurologic presentation and having pathological brain MRI had more sequelae or fatal disease.

First published on February 20, 2008, doi:10.1177/0883073808314151

Journal of Child Neurology 2008;23:1028.

A more recent version of this article appeared on September 1, 2008

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