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Journal of Child Neurology
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0883073808314156v1
23/9/1054    most recent
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Article

Simultaneous Toxicities in a Child on Multiple Anticonvulsants

Sarah Isis R. Delima, Laurence E. Walsh, MD, and Meredith R. Golomb, MD, MSc*

Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis

* To whom correspondence should be addressed. E-mail: mgolomb{at}iupui.edu.


  Abstract
It is rare to develop simultaneous toxicities while on anticonvulsants. This article presents a 31/2-year-old child on valproic acid, lamotrigine, and phenytoin who developed simultaneous hepatotoxicity and bone marrow toxicity during a parainfluenza virus type 3 infection. These toxicities resolved after the cessation of anticonvulsants, and her seizures were managed acutely with scheduled lorazepam. This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk.

First published on March 14, 2008, doi:10.1177/0883073808314156

Journal of Child Neurology 2008;23:1054.

A more recent version of this article appeared on September 1, 2008

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