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Journal of Child Neurology
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0883073808314360v1
23/7/752    most recent
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Article

Simultaneous Guillain-Barré Syndrome and Acute Disseminated Encephalomyelitis in the Pediatric Population

Geneviève Bernard, MD, MSc*, Émilie Riou, MD, Bernard Rosenblatt, MD, FRCPC, Marie-Emmanuelle Dilenge, MD, FRCPC, and Chantal Poulin, MD, FRCPC

Division of Neurology and Neurosurgery, Montreal Children’s Hospital, McGill University, Quebec, Canada

* To whom correspondence should be addressed. E-mail: genevievebernard{at}hotmail.com.


  Abstract
Few cases of simultaneous acute demyelination of the peripheral and central nervous systems are reported. Four patients diagnosed as having Guillain-Barré syndrome and acute disseminated encephalomyelitis during the same hospitalization are described herein. Two patients manifest an atypical form of Guillain-Barré syndrome, with magnetic resonance imaging of the head showing acute disseminated encephalomyelitis. A third patient has acute disseminated encephalomyelitis and develops Guillain-Barré syndrome during his hospitalization. A fourth patient demonstrates transverse myelitis that evolves into Guillain-Barré syndrome, with demyelination seen on brain magnetic resonance imaging. All patients are treated with intravenous immunoglobulins or corticosteroids. Three patients have a favorable outcome; 1 patient has a chronic inflammatory demyelinating polyradiculoneuropathy. Guillain-Barré syndrome and acute disseminated encephalomyelitis can occur simultaneously in the pediatric population. This may be explained by a shared epitope between peripheral and central nervous system myelin. Further research is necessary to better describe this entity and its prognosis.

First published on March 19, 2008, doi:10.1177/0883073808314360

Journal of Child Neurology 2008;23:752.

A more recent version of this article appeared on July 1, 2008

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Home page
 J Child NeurolHome page
E. Wassmer and W. P. Whitehouse
Simultaneous Peripheral and Central Demyelination
J Child Neurol, December 1, 2008; 23(12): 1495 - 1495.
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