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Journal of Child Neurology
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*(L)-ASPARTIC ACID
*CHOLINE BITARTRATE
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Article

1H-Magnetic Resonance Spectroscopy Markers of Cognitive and Language Ability in Clinical Subtypes of Autism Spectrum Disorders

Lidia Gabis, MD1*, Wei Huang, PhD2, Allen Azizian, PhD3, Carla DeVincent, PhD4, Alina Tudorica, PhD5, Yael Kesner-Baruch, MSc1, Patricia Roche, DO5, and John Pomeroy, MBBS, MRCPsych4

1 Weinberg Child Development Center Safra Children’s Hospital at Tel Hashomer, affiliated with the Tel-Aviv University Sackler School of Medicine, Israel
2 Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York
3 Neuropsychiatric Institute and Hospital, University of California at Los Angeles, California
4 Department of Pediatrics, State University of New York at Stony Brook, New York
5 Department of Radiology, State University of New York at Stony Brook, New York

* To whom correspondence should be addressed. E-mail: gabis{at}post.tau.ac.il.


  Abstract
This study assessed metabolic functioning of regional brain areas to address whether there is a neurometabolic profile reflecting the underlying neuropathology in individuals with autism spectrum disorders, and if varied profiles correlate with the clinical subtypes. Thirteen children (7-16 years) with autism spectrum disorders and 8 typically developing children were compared on 1H-magnetic resonance spectroscopy data collected from hippocampus-amygdala and cerebellar regions. The autism spectrum disorder group had significantly lower N-acetyl-aspartate/creatine ratios bilaterally in the hippocampus-amygdala but not cerebellum, whereas myo-inositol/creatine was significantly increased in all measured regions. Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with autism spectrum disorder. Comparisons within the autism spectrum disorder group when clinically subdivided by history of speech delay revealed significant metabolic ratio differences. Magnetic resonance spectroscopy can provide important information regarding abnormal brain metabolism and clinical classification in autism spectrum disorders.

First published on May 16, 2008, doi:10.1177/0883073808315423

Journal of Child Neurology 2008;23:766.

A more recent version of this article appeared on July 1, 2008

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