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Journal of Child Neurology
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*Neuromuscular Disorders
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Article

Neuromuscular Hyperexcitability Associated With Acetylcholine Receptor Antibodies in a Child

Björn Oskarsson, MD1*, Lucyna Zawadzki, MD2, Timothy Benke, MD2, and Dianna Quan, MD1

1 Department of Neurology, University of Colorado Denver, Colorado
2 Department of Pediatrics, Child Neurology Section, University of Colorado Denver, Colorado

* To whom correspondence should be addressed. E-mail: bjorn.oskarsson{at}uchsc.edu.


  Abstract

This report describes the clinical and electrophysiological features of an 8-year-old boy with autoimmune neuromuscular hyperexcitability. He presented with features of lower extremity pain, stiffness, and rippling muscles. The diagnosis was made by electromyography and supported by the presence of an antibody directed against nicotinic acetylcholine receptors. His symptoms responded to immunomodulatory treatment with intravenous immunoglobulin. Response to immunomodulatory therapy has not previously been described in the pediatric population with autoimmune neuromuscular hyperexcitability. This case highlights that this is a treatable condition.

First published on October 20, 2008, doi:10.1177/0883073808320755

Journal of Child Neurology 2009;24:90.

A more recent version of this article appeared on January 1, 2009

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