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Journal of Child Neurology
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*(L)-ASPARTIC ACID
*CHOLINE BITARTRATE
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*Cerebral Palsy
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Article

An Age and Gender Dependency of Metabolite Concentrations in Basal Ganglia in Children with Spastic Diplegia: Proton Magnetic Resonance Spectroscopy Study

Wojciech Kulak, PhD1*, Wojciech Sobaniec, PhD2, Joanna Smigielska-Kuzia, PhD2, Bozena Kubas, PhD3, Bozena Zawada, PhD1, and Dorota Otapowicz, PhD2

1 Department of Pediatric Rehabilitation, Medical University of Bialystok, Bialystok, Poland
2 Department of Pediatric Neurology and Rehabilitation, Medical University of Bialystok, Bialystok, Poland
3 Department of Radiology, Medical University of Bialystok, Bialystok, Poland

* To whom correspondence should be addressed. E-mail: kulak{at}hot.pl.


  Abstract

We determined metabolite profile in spastic diplegic children compared to controls in left basal ganglia of brain in using proton magnetic resonance spectroscopy in correlation with age and gender. Twenty-four patients with spastic diplegia and twenty-six healthy children were examined. The relative concentrations of N-acetylaspartate, choline, and myoinositol were measured in relation to creatine and different combinations of metabolites within 8-cm3 brain voxel. Children with spastic diplegia showed reduced ratios of N-acetylaspartate/creatine, N-acetylaspartate/choline, and N-acetylaspartate/myoinositol in the basal ganglia compared to the control group. Patients and controls subjects demonstrated a significant age-dependent increase in N-acetylaspartate/creatine, N-acetylaspartate/choline in the basal ganglia. No gender-dependent difference was shown in children with cerebral palsy for all tested metabolite ratios. Gender-related differences because of increased ratio N-acetylaspartate/choline in girls in controls were detected. These results indicate that maturation of brain exists in cerebral palsy and healthy children to a higher degree in healthy children.

First published on October 20, 2008, doi:10.1177/0883073808321058

Journal of Child Neurology 2009;24:73.

A more recent version of this article appeared on January 1, 2009

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