This Article Full Text (PDF) All Versions of this Article: 0883073807308694v1 23/1/51    most recent References Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via Web of Science (3) Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Nikas, I. Articles by Theodoropoulos, V. Search for Related Content PubMed PubMed Citation Articles by Nikas, I. Articles by Theodoropoulos, V. Social Bookmarking                         What's this?

Parasagittal Lesions and Ulegyria in Hypoxic-Ischemic Encephalopathy: Neuroimaging Findings and Review of the Pathogenesis

Imaging Department, Agia Sophia Children's Hospital, Athens, Greece

Vasiliki Dermentzoglou, MD

Imaging Department, Agia Sophia Children's Hospital, Athens, Greece

Maria Theofanopoulou, MD

Imaging Department, Agia Sophia Children's Hospital, Athens, martheo2000{at}yahoo.comGreece,

Vasilios Theodoropoulos, MD

Imaging Department, Agia Sophia Children's Hospital, Athens, Greece

Hypoxic-ischemic brain injury is a very important neurological problem of the perinatal period and a major cause of chronic disability later in childhood. The subsequent neurological deficits are a variety of motor defects—especially spasticity but also choreoathetosis, dystonia and ataxia, often grouped together as "cerebral palsy," mental retardation, and seizures. The gestational age determines the neuropathology of the brain injury. One of the patterns of hypoxic-ischemic encephalopathy, typically affecting full-term infants, consists of parasagittal lesions and ulegyria. The aim of this study is to describe the magnetic resonance imaging (MRI) features and discuss the "suggested" pathogenetic mechanisms of this pattern, which affects the cortex and the white matter in a mainly parasagittal distribution; in this type of brain injury, the damage usually involves the deeper sulcal portion while sparing the apex, thus resulting in the so-called mushroom gyri characteristic ulegyric pattern. We discuss the MRI findings of parasagittal lesions and ulegyria in the brain examinations of 14 patients with a clinical history of perinatal hypoxia/anoxia presenting with mental retardation, seizures, and cerebral palsy. Differential diagnosis from polymicrogyria is discussed.

Key Words: parasagittal lesions • ulegyria • hypoxic-ischemic encephalopathy • MRI

This version was published on January 1, 2008

Journal of Child Neurology, Vol. 23, No. 1, 51-58 (2008)
DOI: 10.1177/0883073807308694


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?