Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0883073808315617v1
23/11/1357    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Ledet, D. S.
Right arrow Articles by Khan, R. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ledet, D. S.
Right arrow Articles by Khan, R. B.
Right arrowPubmed/NCBI databases
*Substance via MeSH
Medline Plus Health Information
*Neuromuscular Disorders
*Peripheral Nerve Disorders
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Leucoencephalopathy, Transverse Myelopathy, and Peripheral Neuropathy in Association With Glutamic Acid Decarboxylase-65 (GAD) Antibodies in Children With Cancer

Davonna S. Ledet, MS

Division of Neurology,, St Jude Children's Hospital

Rupert Handgretinger, MD

Department of Bone Marrow Transplant, St Jude Children's Hospital

Tulio E. Bertorini, MD

Department of Neurology University of Tennessee, Memphis

Gregory A. Hale, MD

Department of Bone Marrow Transplant, , St Jude Children's Hospital

Raul C. Ribeiro, MD

Department of Oncology St Jude Children's Research Hospital, St Jude Children's Hospital

Raja B. Khan, MD

Divisions of Neurology and Neuro-Oncology, St Jude Children's Hospital, and Department of Neurology, University of Tennessee, Memphisrkhan{at}neuroclinic.org

Neurologic toxicity may occur as a direct effect of cancer and its therapy or indirectly because of a dysfunctional immune system. The authors report the development of axonal neuropathy, myelopathy, and leucoencephalopathy associated with glutamic acid decarboxylase-65 (GAD) antibodies in 4 children with progressive cancer who were heavily pretreated. Three patients with refractory leukemia and 1 with Ewing sarcoma developed paraplegia with sensory level and dorsal column dysfunction. Three developed leucoencephalopathy and 1 died of neurologic disease. All had high serum titers of GAD antibodies during the progressive phase of the illness, and the antibody levels returned to normal with the stability of the neurologic disease. Three survivors are showing gradual recovery. This syndrome of central and peripheral nervous system toxicity may have resulted from chemotherapy toxicity or from immune dysfunction, as suggested by the high GAD antibody titers.

Key Words: leucoencephalopathy • myelopathy • neuropathy

This version was published on November 1, 2008

Journal of Child Neurology, Vol. 23, No. 11, 1357-1362 (2008)
DOI: 10.1177/0883073808315617
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?