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Journal of Child Neurology
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Intracranial Hypertension in 2 Children With Marfan Syndrome

Yvonne Hilhorst-Hofstee, MD

Center for Human and Clinical Genetics, Leiden University Medical Center, hilhorst{at}lumc.nl

Lucia J. M. Kroft, MD, PhD

Department of Radiology, Leiden University Medical Center

Gerard Pals, PhD

Department of Molecular Genetics, VU University Medical Center, Amsterdam

Jeroen P. P. van Vugt, MD, PhD

Department of Neurology, Medisch Spectrum Twente, Enschede, The Netherlands

Wouterina C. G. Overweg-Plandsoen, MD, PhD

Department of Neurology, Leiden University Medical Center, Leiden

Two unrelated children with Marfan syndrome presented with recurrent intracranial hypertension. Both children complained of headache, nausea, and vomiting and one of them had papilledema. Both had increased cerebrospinal fluid pressure, and their complaints disappeared after lumbar puncture. Although severe headache has been reported in Marfan syndrome due to intracranial hypotension, this is to our knowledge the first report of intracranial hypertension in Marfan patients.

Key Words: Marfan syndrome • connective tissue disorder • intracranial hypertension • headache

This version was published on August 1, 2008

Journal of Child Neurology, Vol. 23, No. 8, 954-955 (2008)
DOI: 10.1177/0883073808315341
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