Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for more information

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
0883073808314156v1
23/9/1054    most recent
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Delima, S. I. R.
Right arrow Articles by Golomb, M. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Delima, S. I. R.
Right arrow Articles by Golomb, M. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Simultaneous Toxicities in a Child on Multiple Anticonvulsants

Sarah Isis R. Delima

Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis

Laurence E. Walsh, MD

Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis

Meredith R. Golomb, MD, MSc

Division of Pediatric Neurology, Department of Neurology, Indiana University School of Medicine, Indianapolis, mgolomb{at}iupui.edu

It is rare to develop simultaneous toxicities while on anticonvulsants. This article presents a 31/2-year-old child on valproic acid, lamotrigine, and phenytoin who developed simultaneous hepatotoxicity and bone marrow toxicity during a parainfluenza virus type 3 infection. These toxicities resolved after the cessation of anticonvulsants, and her seizures were managed acutely with scheduled lorazepam. This article discusses the possibility that simultaneous use of valproic acid, lamotrigine, and phenytoin could give this combination of toxicities and that concurrent viral infection may increase this risk.

Key Words: hepatotoxicity • bone marrow • epilepsy

This version was published on September 1, 2008

Journal of Child Neurology, Vol. 23, No. 9, 1054-1057 (2008)
DOI: 10.1177/0883073808314156
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?