Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here for FREE ACCESS to this landmark database

CiteULike is a free service for managing and discovering scholarly references - click here to get started.

Sign In to gain access to subscriptions and/or personal tools.
Journal of Child Neurology
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Broderick, J.
Right arrow Articles by Brott, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Broderick, J.
Right arrow Articles by Brott, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Stroke in Children Within a Major Metropolitan Area: The Surprising Importance of Intracerebral Hemorrhage

Joseph Broderick, MD

Department of Neurology, University of Cincinnati Medical Center

G. Theodore Talbot, BS

Department of Neurology, University of Cincinnati Medical Center

Erin Prenger, DO

Department of Neuroradiology, Children's Hospital Medical Center, Cincinnati, OH

Alan Leach, BS

Department of Internal Medicine, University of Cincinnati Medical Center

Thomas Brott, MD

Department of Neurology, University of Cincinnati Medical Center

Our objective was to determine the incidence rate of stroke and stroke subtypes in children. We reviewed the medical records, autopsy records, and brain imaging studies of all children with a possible stroke within the Greater Cincinnati metropolitan area population of nearly 1.3 million during 1988 and 1989. Traumatic brain hemorrhages and germinal matrix hemorrhages were excluded. Of the 295,577 children in Greater Cincinnati, medical records of 178 children were screened. Sixteen cases (13 whites and three blacks) less than age 15 years fit strictly defined criteria for first-ever stroke. The incidence rate for cerebral infarction was 1.2 cases per 100,000 (95% confidence interval, 0.3 to 2.0). The combined incidence rate for intracerebral hemorrhage and subarachnoid hemorrhage was 1.5 cases per 100,000 children (95% confidence interval, 0.4 to 2.3). The incidence rate of all stroke in white children was 2.6 cases per 100,000 (95% confidence interval, 1.2 to 4.1), compared to 3.1 per 100,000 in black children (95% confidence interval, 0 to 6.6). The combined 30-day mortality for intracerebral hemorrhage and subarachnoid hemorrhage was 22% (two of nine) compared to 14% (one of seven) for cerebral infarction. We conclude that in contrast to the picture in adults, hemorrhagic stroke among infants and children is at least as common as ischemic infarction. (J Child Neurol 1993;8:250-255).

Journal of Child Neurology, Vol. 8, No. 3, 250-255 (1993)
DOI: 10.1177/088307389300800308
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 StrokeHome page
N. Agrawal, S. C. Johnston, Y. W. Wu, S. Sidney, and H. J. Fullerton
Imaging Data Reveal a Higher Pediatric Stroke Incidence Than Prior US Estimates
Stroke, November 1, 2009; 40(11): 3415 - 3421.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
I. Zak, B. Sarecka-Hujar, I. Kopyta, E. Emich-Widera, E. Marszal, J. Wendorff, and J. Jachowicz-Jeszka
The T Allele of the 677C>T Polymorphism of Methylenetetrahydrofolate Reductase Gene is Associated With an Increased Risk of Ischemic Stroke in Polish Children
J Child Neurol, October 1, 2009; 24(10): 1262 - 1267.
[Abstract] [PDF]

Home page
 NeurologyHome page
J. Armstrong-Wells, B. Grimes, S. Sidney, D. Kronish, S. C. Shiboski, R. J. Adams, and H. J. Fullerton
Utilization of TCD screening for primary stroke prevention in children with sickle cell disease
Neurology, April 14, 2009; 72(15): 1316 - 1321.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
J. Armstrong-Wells, S. C. Johnston, Y. W. Wu, S. Sidney, and H. J. Fullerton
Prevalence and Predictors of Perinatal Hemorrhagic Stroke: Results From the Kaiser Pediatric Stroke Study
Pediatrics, March 1, 2009; 123(3): 823 - 828.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
M. Arnold, M. Steinlin, A. Baumann, K. Nedeltchev, L. Remonda, S. J. Moser, M.-L. Mono, G. Schroth, H. P. Mattle, and R. W. Baumgartner
Thrombolysis in Childhood Stroke: Report of 2 Cases and Review of the Literature
Stroke, March 1, 2009; 40(3): 801 - 807.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
W. Lo, J. Stephens, and S. Fernandez
Pediatric Stroke in the United States and the Impact of Risk Factors
J Child Neurol, February 1, 2009; 24(2): 194 - 203.
[Abstract] [PDF]

Home page
 PediatricsHome page
J. G. Donahue, B. A. Kieke, W. K. Yih, N. R. Berger, J. S. McCauley, J. Baggs, K. M. Zangwill, R. Baxter, E. M. Eriksen, J. M. Glanz, et al.
Varicella Vaccination and Ischemic Stroke in Children: Is There an Association?
Pediatrics, February 1, 2009; 123(2): e228 - e234.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
L. C. Jordan, S. C. Johnston, Y. W. Wu, S. Sidney, and H. J. Fullerton
The Importance of Cerebral Aneurysms in Childhood Hemorrhagic Stroke: A Population-Based Study
Stroke, February 1, 2009; 40(2): 400 - 405.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
W. D. Lo, J. Lee, J. Rusin, E. Perkins, and E. S. Roach
Intracranial Hemorrhage in Children: An Evolving Spectrum
Arch Neurol, December 1, 2008; 65(12): 1629 - 1633.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
E. S. Roach, M. R. Golomb, R. Adams, J. Biller, S. Daniels, G. deVeber, D. Ferriero, B. V. Jones, F. J. Kirkham, R. M. Scott, et al.
Management of Stroke in Infants and Children: A Scientific Statement From a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young
Stroke, September 1, 2008; 39(9): 2644 - 2691.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. J. Adams
Big Strokes in Small Persons
Arch Neurol, November 1, 2007; 64(11): 1567 - 1574.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
H. J. Fullerton, Y. W. Wu, S. Sidney, and S. Claiborne Johnston
Recurrent Hemorrhagic Stroke in Children: A Population-Based Cohort Study
Stroke, October 1, 2007; 38(10): 2658 - 2662.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
D. L. Labovitz, M. R. Golomb, B. P. Garg, C. Saha, and L. S. Williams
ACCURACY AND YIELD OF ICD-9 CODES FOR IDENTIFYING CHILDREN WITH ISCHEMIC STROKE
Neurology, May 8, 2007; 68(19): 1638 - 1638.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
M.-J. Tsai, W.-C. Lin, C.-H. Kuo, H.-F. Chou, and R.-C. Yang
Acute Midbrain Infarction in a Child With Intracranial Carotid Artery Hypoplasia and Aberrant Cerebral Vasculature: A Case Report
J Child Neurol, April 1, 2007; 22(4): 465 - 470.
[Abstract] [PDF]

Home page
 CirculationHome page
W. Rosamond, K. Flegal, G. Friday, K. Furie, A. Go, K. Greenlund, N. Haase, M. Ho, V. Howard, B. Kissela, et al.
Heart Disease and Stroke Statistics--2007 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Circulation, February 6, 2007; 115(5): e69 - e171.
[Full Text] [PDF]

Home page
 J Child NeurolHome page
N. Akar, B. Donmez, and G. Deda
FXIII Gene Val34Leu Polymorphism in Turkish Children with Cerebral Infarct
J Child Neurol, February 1, 2007; 22(2): 222 - 224.
[Abstract] [PDF]

Home page
 NeurologyHome page
D. Hirtz, D. J. Thurman, K. Gwinn-Hardy, M. Mohamed, A. R. Chaudhuri, and R. Zalutsky
How common are the "common" neurologic disorders?
Neurology, January 30, 2007; 68(5): 326 - 337.
[Abstract] [Full Text] [PDF]

Home page
 J Trop PediatrHome page
N. Aydinli, B. Tatli, M. Caliskan, M. Ozmen, A. Citak, A. Unuvar, T. Baykal, R. E. Omeroglu, K. Aydin, S. Sencer, et al.
Stroke in Childhood: Experience in Istanbul, Turkey
J Trop Pediatr, June 1, 2006; 52(3): 158 - 162.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
D. Kleindorfer, J. Khoury, B. Kissela, K. Alwell, D. Woo, R. Miller, A. Schneider, C. Moomaw, and J. P. Broderick
Temporal Trends in the Incidence and Case Fatality of Stroke in Children and Adolescents
J Child Neurol, May 1, 2006; 21(5): 415 - 418.
[Abstract] [PDF]

Home page
 CirculationHome page
T. Thom, N. Haase, W. Rosamond, V. J. Howard, J. Rumsfeld, T. Manolio, Z.-J. Zheng, K. Flegal, C. O'Donnell, S. Kittner, et al.
Heart Disease and Stroke Statistics--2006 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Circulation, February 14, 2006; 113(6): e85 - e151.
[Full Text] [PDF]

Home page
 StrokeHome page
H. Fullerton, J. K. Lynch, and G. deVeber
The Call for Multicenter Studies of Pediatric Stroke
Stroke, February 1, 2006; 37(2): 330 - 331.
[Full Text] [PDF]

Home page
 StrokeHome page
H. J. Fullerton, A. S. Achrol, S. C. Johnston, C. E. McCulloch, R. T. Higashida, M. T. Lawton, S. Sidney, W. L. Young, and For the UCSF BAVM Study Project
Long-Term Hemorrhage Risk in Children Versus Adults With Brain Arteriovenous Malformations
Stroke, October 1, 2005; 36(10): 2099 - 2104.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
D. B. Zahuranec, D. L. Brown, L. D. Lisabeth, and L. B. Morgenstern
Is It Time for a Large, Collaborative Study of Pediatric Stroke?
Stroke, September 1, 2005; 36(9): 1825 - 1829.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
S Haywood, R Liesner, S Pindora, and V Ganesan
Thrombophilia and first arterial ischaemic stroke: a systematic review
Arch. Dis. Child., April 1, 2005; 90(4): 402 - 405.
[Abstract] [Full Text] [PDF]

Home page
 CLIN PEDIATRHome page
K. Saxena, M. Ranalli, N. Khan, C. Blanchong, and S. B. Kahwash
Fatal Stroke in a Child with Severe Iron Deficiency Anemia and Multiple Hereditary Risk Factors for Thrombosis
Clinical Pediatrics, March 1, 2005; 44(2): 175 - 180.
[PDF]

Home page
 CLIN APPL THROMB HEMOSTHome page
R. Duran, B. Biner, M. Demir, C. Celtik, and S. Karasalihoglu
Factor V Leiden Mutation and Other Thrombophilia Markers in Childhood Ischemic Stroke
Clinical and Applied Thrombosis/Hemostasis, January 1, 2005; 11(1): 83 - 88.
[Abstract] [PDF]

Home page
 ChestHome page
P. Monagle, A. Chan, P. Massicotte, E. Chalmers, and A. D. Michelson
Antithrombotic Therapy in Children*: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy
Chest, September 1, 2004; 126(3_suppl): 645S - 687S.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
B. Chung and V. Wong
Pediatric Stroke Among Hong Kong Chinese Subjects
Pediatrics, August 1, 2004; 114(2): e206 - e212.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
H. J. Fullerton, R. J. Adams, S. Zhao, and S. C. Johnston
Declining stroke rates in Californian children with sickle cell disease
Blood, July 15, 2004; 104(2): 336 - 339.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
A. Kirton, J. H. Wong, J. Mah, B. C. Ross, J. Kennedy, K. Bell, and M. D. Hill
Successful Endovascular Therapy for Acute Basilar Thrombosis in an Adolescent
Pediatrics, September 1, 2003; 112(3): e248 - 251.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H. J. Fullerton, Y. W. Wu, S. Zhao, and S. C. Johnston
Risk of stroke in children: Ethnic and gender disparities
Neurology, July 22, 2003; 61(2): 189 - 194.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
A. D. Patsalides, L. V. Wood, G. K. Atac, E. Sandifer, J. A. Butman, and N. J. Patronas
Cerebrovascular Disease in HIV-Infected Pediatric Patients: Neuroimaging Findings
Am. J. Roentgenol., October 1, 2002; 179(4): 999 - 1003.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
H.J. Fullerton, D.M. Chetkovich, Y.W. Wu, W.S. Smith, and S.C. Johnston
Deaths from stroke in US children, 1979 to 1998
Neurology, July 9, 2002; 59(1): 34 - 39.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
J. K. Lynch, K. B. Nelson, C. J. Curry, and J. K. Grether
Cerebrovascular Disorders in Children With the Factor V Leiden Mutation
J Child Neurol, October 1, 2001; 16(10): 735 - 744.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
K. S. Carvalho, J. B. Bodensteiner, P. J. Connolly, and B. P. Garg
Cerebral Venous Thrombosis in Children
J Child Neurol, August 1, 2001; 16(8): 574 - 580.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
N. Akar, E. Akar, E. Yilmaz, and G. Deda
Plasminogen Activator Inhibitor-1 4G/5G Polymorphism in Turkish Children With Cerebral Infarct and Effect on Factor V 1691 A Mutation
J Child Neurol, April 1, 2001; 16(4): 294 - 295.
[Abstract] [PDF]

Home page
 StrokeHome page
G. Kenet, S. Sadetzki, H. Murad, U. Martinowitz, N. Rosenberg, S. Gitel, G. Rechavi, and A. Inbal
Factor V Leiden and Antiphospholipid Antibodies Are Significant Risk Factors for Ischemic Stroke in Children
Stroke, June 1, 2000; 31(6): 1283 - 1288.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
A. Al-Jarallah, M. T. Al-Rifai, A. R. Riela, and E. S. Roach
Nontraumatic Brain Hemorrhage in Children: Etiology and Presentation
J Child Neurol, May 1, 2000; 15(5): 284 - 289.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
G. A. deVeber, D. MacGregor, R. Curtis, and S. Mayank
Neurologic Outcome in Survivors of Childhood Arterial Ischemic Stroke and Sinovenous Thrombosis
J Child Neurol, May 1, 2000; 15(5): 316 - 324.
[Abstract] [PDF]

Home page
 NeurologyHome page
S. Lanthier, L. Carmant, M. David, A. Larbrisseau, and G. de Veber
Stroke in children: The coexistence of multiple risk factors predicts poor outcome
Neurology, January 25, 2000; 54(2): 371 - 371.
[Abstract] [Full Text] [PDF]

Home page
 J Child NeurolHome page
N. Akar, E. Akar, G. Deda, T. Sipahi, and A. Orsal
Factor V1691 G-A, Prothrombin 20210 G-A, and Methylenetetrahydrofolate Reductase 677 C-T Variants in Turkish Children With Cerebral Infarct
J Child Neurol, November 1, 1999; 14(11): 749 - 751.
[Abstract] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
G. Kenet, J. Freedman, B. Shenkman, E. Regina, F. Brok-Simoni, F. Holzman, F. Vavva, N. Brand, A. Michelson, M. Trolliet, et al.
Plasma Glutathione Peroxidase Deficiency and Platelet Insensitivity to Nitric Oxide in Children With Familial Stroke
Arterioscler Thromb Vasc Biol, August 1, 1999; 19(8): 2017 - 2023.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
F J Kirkham
Stroke in childhood
Arch. Dis. Child., July 1, 1999; 81(1): 85 - 89.
[Full Text]

Home page
 CirculationHome page
I. M. van Beynum, J. A. M. Smeitink, M. den Heijer, M. T. W. B. te Poele Pothoff, and H. J. Blom
Hyperhomocysteinemia : A Risk Factor for Ischemic Stroke in Children
Circulation, April 27, 1999; 99(16): 2070 - 2072.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
G. deVeber, A. Chan, P. Monagle, V. Marzinotto, D. Armstrong, P. Massicotte, M. Leaker, and M. Andrew
Anticoagulation Therapy in Pediatric Patients With Sinovenous Thrombosis: A Cohort Study
Arch Neurol, December 1, 1998; 55(12): 1533 - 1537.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
G. deVeber, P. Monagle, A. Chan, D. MacGregor, R. Curtis, S. Lee, P. Vegh, M. Adams, V. Marzinotto, M. Leaker, et al.
Prothrombotic Disorders in Infants and Children With Cerebral Thromboembolism
Arch Neurol, December 1, 1998; 55(12): 1539 - 1543.
[Abstract] [Full Text] [PDF]

Home page
 StrokeHome page
J. Broderick, T. Brott, R. Kothari, R. Miller, J. Khoury, A. Pancioli, J. Gebel, D. Mills, L. Minneci, and R. Shukla
The Greater Cincinnati/Northern Kentucky Stroke Study : Preliminary First-Ever and Total Incidence Rates of Stroke Among Blacks
Stroke, February 1, 1998; 29(2): 415 - 421.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
A Connelly, W K Chong, C L Johnson, V Ganesan, D G Gadian, and F J Kirkham
Diffusion weighted magnetic resonance imaging of compromised tissue in stroke
Arch. Dis. Child., July 1, 1997; 77(1): 38 - 41.
[Abstract] [Full Text]

Home page
 J Child NeurolHome page
J. Mancini, N. Girard, B. Chabrol, S. Lamoureux, M.-O. Livet, I. Thuret, and N. Pinsard
Ischemic Cerebrovascular Disease in Children: Retrospective Study of 35 Patients
J Child Neurol, April 1, 1997; 12(3): 193 - 199.
[Abstract] [PDF]

Home page
 J Child NeurolHome page
A. R. Riela and E. S. Roach
Topical Review Article: Etiology of Stroke in Children
J Child Neurol, July 1, 1993; 8(3): 201 - 220.
[Abstract] [PDF]